Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics.

This article describes how and why NAD (Nicotinamide adenine dinucleotide) and the so called “NAD-boosting molecules” (such as niacin, niacinamide, nicotinamide riboside, nicotinamide mononucleotide) are so important for human health and metabolism.

This article describes the beneficial effects of NAD and its precursor niacin (Vitamin B3) to human skin, and how niacin deficiency in humans causes several dermatological diseases and sun sensitivity, indicative of DNA damages. Furthermore, the authors report on various studies which have provided links to niacin’s role as a potential skin cancer prevention agent, sustaining proper DNA damage repair and maintenance of genomic stability, as well as driving skin differentiation to create a proper skin barrier and function.

This article describes an in-vivo study on the percutaneous penetration of several organic chemicals, including nicotinic acid (niacin) and niacinamide, after application to the human forearm and quantitating the penetration of each chemical through the skin by its appearance in urine.

Nicomenthyl 20 is a multifunctional sensorial cosmetic active, derived from vitamin B3 (niacin or nicotinic acid), manufactured in Italy by Multichem R&D, through a patented synthesis process.

Nicomenthyl 20 significantly enhances skin microcirculation, without causing hyperemia or irritation. At the contrary, it produces a localized pleasant tingling sensation.

NICOMENTHYL® 20 is composed of pure MENTHYL NICOTINATE, with no residues of other nicotinates, obtained through a new and proprietary industrial synthesis process, developed over 20 years of research by Dr. Gabriele Segalla at Multichem R&D Laboratories, in Milan, Italy. NICOMENTHYL 20 represents a new and revolutionary substance for cosmetic use that can significantly activate the cutaneous microcirculation without causing bothersome hyperemia or irritations, on the contrary it generates a pleasant hot-cold sensation in the area of application.